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Updated: Aug 7, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

タモキシフェンはコレステロールを7倍減らし,アポリポプロテインEノックアウトマウスの脂質病変の発症を廃止する

J Reckless1, J C Metcalfe, D J Grainger

  • 1Department of Biochemistry, University of Cambridge, UK. jr3@mole.bio.cam.ac.uk

Circulation
|March 18, 1997
PubMed
まとめ

タモキシフェン (TMX) 治療は,アポリポプロテインE (apo E) ノックアウトマウスにおける脂質の病変を著しく減少させ,コレステロールとトリグリセリドを低下させました. これは,リポタンパク質のプロフィールを変化させ,TGF-βを増加させることで,TMXが心血管の保護を提供する可能性があることを示唆しています.

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