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Updated: Jul 15, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

カスパゼ-1はIFN-ガンマ誘導因子を処理し,LPS誘導のIFN-ガンマ生成を調節する

T Ghayur1, S Banerjee, M Hugunin

  • 1BASF Bioresearch Corporation, Worcester, Massachusetts 01605-4314, USA. ghayur@biovax.dnet.basf-ag.de

Nature
|April 10, 1997
PubMed
まとめ

インタールイキン-18 (IGIF) の成熟には,IL-1βの産生に関与するプロテアゼであるカスパーゼ-1が必要です. Caspase-1の抑制または欠乏は炎症性サイトカインの産生を減少させ,新しい抗炎症薬の標的を示唆する.

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