フィブロブラスト成長因子受容体のチロシンキナーゼドメインの構造は,阻害剤との複合体である

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Updated: Aug 15, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

M Mohammadi1, G McMahon, L Sun

  • 1Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA.

Science (New York, N.Y.)
|May 9, 1997
PubMed
まとめ

研究者らは,線維芽細胞成長因子受容体1 (FGFR1) キナーゼ活性を標的とした新しいオキシンドールベースの阻害剤を発見した. 構造分析は,チロシンキナーゼを標的とした新しいがん治療薬の開発に不可欠な結合機構を明らかにします.

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