臨床的に認められた不形成性ネビ. 皮膚性メラノーマの主要な危険因子です
M A Tucker1, A Halpern, E A Holly
1Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md, 20892-7372, USA. tuckerp@epndce.nci.nih.gov
JAMA
|May 14, 1997
まとめ
モールの数とタイプは,メラノーマのリスクに大きな影響を与えます. 特に臨床的に不整形性ネボは,かなりのリスクを伴うため,早期介入のための高リスクの個人を特定することができます.
科学分野:
- 皮膚科 皮膚科について
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- メラノーマは,公衆衛生上の重大な懸念事項である.
- ネヴィ (モール) は一般的な皮膚病変であり,メラノーマ発症との関連については,さらなる解明が必要である.
研究 の 目的:
- ネビの数量と特徴とメラノーマの発生率との関連を調査する.
- メラノーマのリスクが高いことを示す特定のネブスタイプとカウントを特定するために.
主な方法:
- 716人のメラノーマ患者と1014人の対照群を対象に,症例対照研究が行われました.
- データ収集には,インタビュー,全皮膚検査,非典型性ネヴィウの撮影/生検が含まれていました.
主要な成果:
- メラノーマのリスクは,小さなネブ,大きな非ディスプラスティックネブ,および臨床的にディスプラスティックネブの数と強く相関しています.
- 1つの臨床的に不整形性ネブスはメラノーマのリスクを2倍に,10個以上は12倍に増加させました.
- 生まれながらのネビは,メラノーマのリスクの増加との関連を示さなかった.
結論:
- 臨床的に不形成性ネボは,メラノーマ発症の重大な危険因子です.
- ノンディスプラスティックネボはリスクが小さくなりますが,その量は依然として重要です.
- ネウスの特徴は,臨床医がメラノーマのリスクの高い患者を特定し,標的型スクリーニングと予防戦略を促進するのに役立ちます.
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