ヒトのB型リンパ球とゼロ型リンパ球は,単一の免疫グロブリン群を形成するのでしょうか?
Lancet (London, England)
|November 17, 1979
まとめ
ヒトのゼロリンパ球は,典型的なB細胞とT細胞マーカーが欠けていて,特定の検査で検出可能な表面免疫グロブリン (smIg) を発現します. これは,Bリンパ球の定義をBリンパ球を含むように拡張することを示唆し,自然殺人細胞の役割を明らかにする可能性がある.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 血液学 ヘマトロジ
背景:
- 人間のリンパ球は,表面マーカーに基づいて,伝統的にB細胞またはT細胞として分類されています.
- ゼロリンパ球には,Bリンパ球とTリンパ球の両方の従来のマーカーが欠けている.
- 表面膜免疫グロブリン (smIg) はB型リンパ球の主要なマーカーである.
研究 の 目的:
- 人間のゼロリンパ球に表層免疫グロブリン (smIg) の決定因子の存在を調査する.
- 新しい発見に基づいて,Bリンパ球の拡張された定義を提案する.
- 自然性および抗体依存性キラー細胞を理解するための意味を探求する.
主な方法:
- smIg.を検出するための直接免疫光.
- smIgの決定因子を示すために,直接抗グローブリンおよび混合抗グローブリンロゼット試験を行います.
主要な成果:
- ゼロリンパ球にはTリンパ球マーカーと,従来的に検出可能なsmIgが欠けている.
- ほとんどのゼロリンパ球は,抗グローブリンとロゼット検査で実証可能なsmIgの決定因子を発現します.
- これは,ゼロリンパ球がBリンパ球と特徴を共有していることを示唆しています.
結論:
- Bリンパ球の定義は,抗グローブリンとロゼット検査で検出されるゼロ細胞を含むように拡大されるべきである.
- Bリンパ球の異質性を認識することで,天然のキラー細胞と抗体依存のキラー細胞の機能を明確にすることができる.
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