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Updated: Jul 26, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
11:28

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Published on: March 31, 2012

RhoのGln63は,Escherichia coliの細胞毒性ネクロチズファクター-1によってデアミド化される

G Schmidt1, P Sehr, M Wilm

  • 1Institut für Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Germany.

Nature
|June 12, 1997
PubMed
まとめ

Escherichia coli cytotoxic necrotizing factor 1 (CNF1) は,Gln 63をデアミダートし,そのGTPaseの活性を阻害することによって,RhoAを無効化する. この改変により,構成的に活性なRhoAタンパク質が生み出され,アクチン細胞骨格の調節に影響を与えます.

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