ウサギの自己抗原に対する抗体反応の特異性

R Jemmerson, E Margoliash

Nature

|November 29, 1979

まとめ

ウサギのサイトクロームc

科学分野:

進化生物学の進化生物学について
免疫学免疫学とは

背景:

サイトクロームcは,細胞呼吸における重要なタンパク質です.
抗原決定因子は免疫反応を誘発する.

研究の目的:

細胞染色体cに対する進化的圧力を調査する.
免疫自己耐性の基礎を理解する.

主な方法:

哺乳類種間のサイトクロームc配列の分析.
ウサギの抗体と哺乳類のサイトクロームcを用いた免疫学的研究.

主要な成果:

ウサギのサイトクロームcの抗原部位は,他の哺乳類と比較して変動する領域で発見されています.
これらの変数領域は,おそらく免疫認識のターゲットを表しています.

結論:

進化過程は,自己決定因子の遺伝的特異性を排除して,自己免疫反応を防ぐことができる.
これは,進化の過程で自己耐性を維持するメカニズムを示唆しています.

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