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Updated: May 4, 2026

Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters
09:22

Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters

Published on: November 27, 2013

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RARアルファ活性化機能AF-1の刺激は,一般転写因子TFIIHと結合し,CDK7によるリン酸化によって行われる

C Rochette-Egly1, S Adam, M Rossignol

  • 1Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, Collège de France, Illkirch, Strasbourg.

Cell
|July 11, 1997
PubMed
まとめ

レチノイド酸受容体α (RARα) の活性度は,Ser-77のリン酸化に依存する. サイクリン依存キナーゼ7 (CDK7) と転写因子TFIIHはRARααを結合し,リン酸化し,トランザクティベーション機能を強化する.

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

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