Pax6は,階層化されたShhシグナル伝達に反応して,原始細胞のアイデンティティとニューロンの運命を制御する
J Ericson1, P Rashbass, A Schedl
1Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Cell
|July 11, 1997
まとめ
ソニック・ヘッジホッグ (Shh) 信号パターンは,独特のモーターニューロンと腹部内ニューロン. 先生細胞におけるPax6とNkx2.2の遺伝子発現は,脊髄におけるShh媒介ニューロン発達の鍵となる.
科学分野:
- 発達神経生物学について
- 分子神経科学は分子神経科学である.
- 遺伝子規制ネットワークとは
背景:
- ソニック・ヘッジホッグ (Shh) は,胚の発達における重要なシグナル伝達分子である.
- シュシュ・グラディエントは腹部神経管のパターンを形成し,細胞の運命決定に影響を与えます.
- 転写因子Pax6とNkx2.2は,腹腔のパターン形成において重要な役割を果たしています.
研究 の 目的:
- 異なるニューロンのサブタイプを生成するSonic hedgehog (Shh) 信号伝達の役割を明らかにする.
- Shhシグナル伝達が,Pax6とNkx2.2発現によって定義された原始細胞集団をどのように確立するかを調査する.
- ニューロンのアイデンティティのためのShhのグレード化されたシグナル伝達を媒介するPax6の貢献を理解するために.
主な方法:
- 静脈神経管の祖先における遺伝子発現パターン (Pax6, Nkx2.2) の分析.
- 神経細胞の運命を決定する Shh 信号グラデーションの影響を調査.
- Shh信号伝達経路を媒介するPax6の役割に関する機能的研究.
主要な成果:
- シュシュシグナル伝達活動は,腹部神経管の原始細胞集団を評価する.
- Pax6 と Nkx2.2 の発現によって定義される明確な祖先集団は,Shh.によって確立されています.
- Pax6は,腹部原始ドメインを確立し,モーターニューロンと内部ニューロンのアイデンティティを特定する上で重要な役割を果たします.
結論:
- Shh信号は,モーターニューロンと腹部内ニューロンの段階的な生成に不可欠です.
- Pax6は,Shhのグレード化されたシグナル伝達の主要な媒介者として作用し,ニューロンの祖先のアイデンティティを制御します.
- Shh,Pax6とNkx2.2の相互作用は,中枢神経管のパターニングとニューロンの分化をオーケストラする.
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