早期のBCGワクチン接種とアトピー発症
J S Alm1, G Lilja, G Pershagen
1Sachs' Children's Hospital, Stockholm, Sweden.
Lancet (London, England)
|August 9, 1997
まとめ
早期のBCGワクチン接種は,家族歴にアトピーがある子供のアトピー疾患の発症に影響を与えないようです. この研究では,ワクチン接種と予防接種を受けていない子どもの間で,アトピー病の発生率に有意な差は認められませんでした.
科学分野:
- 免疫学 免疫学とは
- 小児科は小児科です.
- アレルギー アレルギー アレルギー
背景:
- アトピー病の発生率の上昇は,感染症の減少や小児予防接種スケジュールの変更と相関する可能性があります.
- アトピー発現に対するバチルス・カルメッテ・ゲーリン (BCG) ワクチン接種の潜在的影響を調査した.
研究 の 目的:
- 早期のBCGワクチン接種が,予備性のある小児におけるアトピー病の発生率に影響するかどうかを判断する.
主な方法:
- アトピー性遺伝を持つBCGワクチン接種を受けた216人と,ワクチン接種を受けていない358人の子どもを対象とした,遡及的なコホート研究.
- 子供は,アトピー史,臨床症状,皮膚刺傷検査 (SPT),および血清アレルゲン固有のIgEレベルについて評価されました.
- 親の血清もIgE抗体について分析した.
主要な成果:
- BCGワクチン接種 (36%) と未接種 (41%) の子供の間で,アトピー病の罹患率が有意な差異はない.
- 陽性SPTと循環するアレルゲン固有のIgE抗体の割合は,両群とも同様でした.
- アトピー症は,各グループの子供の約3分の2の親に確認され,他のリスク要因は均等に分布していた.
結論:
- 早期のBCGワクチン接種は,アトピー性遺伝を持つ子供の学齢前のアトピー病の発症に影響を与えないようです.
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