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Updated: Aug 11, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
10:37

Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

小型のGタンパク質の結晶構造は,GTPアゼ活性化タンパク質であるrhoGAPAPと複合しています

K Rittinger1, P A Walker, J F Eccleston

  • 1National Institute for Medical Research, London, UK.

Nature
|August 14, 1997
PubMed
まとめ

Cdc42Hsのような小さなGタンパク質は,分子スイッチとして作用することで細胞機能を調節します. この研究では,GTPアナログに結合したCdc42Hsの結晶構造とp50rhoGAPとの相互作用を明らかにし,GTP水解調節を解明しました.

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Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization09:19

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