高齢者における胃酸性

A Hurwitz¹, D A Brady, S E Schaal

¹Department of Medicine, University of Kansas Medical Center, Kansas City 66160-7320, USA. ahurwitz@kumc.edu

JAMA

|August 27, 1997

まとめ

ほとんどの高齢者は胃酸を保ち,以前の信念に異議を唱える. 一部の高齢者の低酸性は,縮性胃炎と関連しており,さらなる研究が必要であることを示しています.

科学分野:

胃腸内科胃腸内科
ゲリアトリクスゲリアトリクス
内科内科は,内科の内科である.

背景:

従来の知恵は,年齢とともに胃酸度が低下することを示唆していました.
しかし,高齢者におけるアクロヒドリアの続発の稀さは,この概念に疑問を投げかけました.

研究の目的:

高齢者における基礎胃酸の有病率を決定する.
この集団における血清ペプシノゲン比率を用いて,縮性胃炎の流行を評価する.

主な方法:

248人の独立した高齢のボランティア (65歳以上) を対象とした横断的な研究です.
キニニウム樹脂を用いた基礎胃酸分泌の非侵襲的評価.
血清ペプシノゲンI/II比 (<2.9) に基づくアトロフィック胃炎の診断

主要な成果:

84%の被験者が基礎状態で胃酸含有量 (pH <3.5) を示した.
罹患率の推定値:67%一貫した酸分泌,22%断続的,11%一貫して高いpH.
一貫した低分泌体 (低酸性) は,酸分泌体 (5%) と比較して,縮性胃炎 (67%) の高い流行を示しました.

結論:

一般的な考えに反して,ほとんどの高齢者は胃酸の分泌能力を保持しています.
高齢者の低胃酸は,アトロフィック性胃炎と有意に関連しています.
研究結果は,年齢に関係する胃酸性低下の再評価が正当であることを示唆しています.

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