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Updated: May 11, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Published on: December 9, 2015

哺乳類のフェロモン受容体の多様な配列をコードする多遺伝子ファミリー

H Matsunami1, L B Buck

  • 1Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Cell
|August 22, 1997
PubMed
まとめ

哺乳類は,特定の匂いを検知するために,吐口鼻臓器にあるフェロモン受容体 (VR) の新しいファミリーを使用します. これらの受容体は分散したパターンで発現し,複雑な感覚コーディングシステムを示唆しています.

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...