コレステロール濃度が低いアメリカ先住民の血清コレステロールと死亡率:U形の関連
A Fagot-Campagna1, R L Hanson, K M Narayan
1National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Ariz 85014, USA. fax@cu.nih.gov
Circulation
|October 7, 1997
まとめ
低血清コレステロールは,直接死の原因にはなりません. 代わりに,病気によってコレステロールレベルが低下し,ピマ・インディアンの死亡率が高いとの関連が見られる.
科学分野:
- エピデミオロジー エピデミオロジー
- バイオケミストリー バイオケミストリー
背景:
- 低血清コレステロールは,癌,トラウマ,感染症による死亡率の増加と論争の的になっている.
- 低コレステロールと死亡率の因果関係は,さらなる調査を必要としています.
研究 の 目的:
- 低血清コレステロールが全原因または特定原因による死亡の因果要因であるかどうかを評価する.
- ピマ・インディアンの集団におけるコレステロールレベルと死亡率の複雑な関係を調査する.
主な方法:
- 4553人のピマ・インディアン (年齢>=20) の長期的研究で,追跡期間の中央値は12.8年であった.
- 血清コレステロールは2年ごとに測定され,死亡率は比例リスクモデルを用いて分析された.
- 統計分析における潜在的な混同要因に調整した.
主要な成果:
- 血清コレステロールと全死因の死亡率の間にU形の関係が観察されました.
- コレステロールと心血管疾患/糖尿病の死亡率の間の肯定的な関連性が見つかりました.
- コレステロールと癌/アルコール関連疾患による死亡率の間の否定的な関連性; 感染症のU型.
結論:
- 低コレステロールと高い死亡率との間の観察された関連は,低コレステロールが病気を引き起こすのではなく,コレステロールを低下させる疾患によるものである可能性が高い.
- これは,病気が先行し,コレステロールレベルに影響を与える逆因果関係を示唆しています.
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