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アメリカ先住民における左心室質量と人口統計学的および血液動力学的変数の関係: 強い心臓の研究
R B Devereux1, M J Roman, G de Simone
1Department of Medicine, The New York Hospital-Cornell Medical Center, NY 10021, USA. rbdevere@mail.med.cornell.edu
Circulation
|October 7, 1997
まとめ
左心室の質量は,脳卒中の量と収縮効率によって最もよく予測され,人口統計学的要因も役割を果たします. 腹腔質量の変動のほぼ半分は,これらの要因によって説明されないままです.
科学分野:
- 心臓病学 心臓病学
- 生理学 生理学とは
- バイオ統計学 バイオ統計学
背景:
- 以前の研究では,左心室 (LV) 質量が人口統計と血液動力学に関連していた.
- これらの因子のLV質量に対する独立した貢献は,以前は知られていなかった.
研究 の 目的:
- LV質量の人口統計学的および血液動力学的予測者の相対的な強さと独立性を決定する.
- 左心室質量に影響を与える重要な要因を特定するために.
主な方法:
- 1935年のアメリカン・インディアン参加者におけるLV質量を評価するために,エコーカルディオグラフィーが使用されました.
- LV質量と人口統計学的変数,血圧,脳卒中量 (SV),収縮度測定値との関係を分析した.
- LV質量の独立した相関値を特定するために,多変量分析が行われました.
主要な成果:
- ストローク・ボリューム (SV) と収縮率の測定値 (ストレスの影響を受けない中壁の断片的縮小) は,静脈血圧よりもLV質量の強い予測指標であった.
- 身長,体重,体量指数などの人口統計学的変数も重要な予測要因でした.
- 血液動力学的および人口学的要因を含む多変量モデルは,LV質量の変動の最大51%を説明しました.
結論:
- 血液動力学的要因,特に脳卒中の体積と収縮効率は,血圧単独と比較して,LV質量の予測を大幅に改善します.
- 人口統計学的変数を組み込むことは,LVの質量予測をさらに強化します.
- 左心室の質量変動の大部分は説明されていないまま,他の測定されていない要因が関与していることを示唆しています.
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