大人における慢性呼吸器系の症状の反応性,発達および寛解
X Xu1, B Rijcken, J P Schouten
1Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
Lancet (London, England)
|November 26, 1997
まとめ
ヒスタミンに対する呼吸道反応の増大は,新しい慢性呼吸器系の症状を予測し,成人では症状の寛解を妨げます. この発見は,肺疾患の発生と持続におけるその役割を強調しています.
科学分野:
- 肺内医学 肺内医学 肺内医学
- 呼吸器生理学 呼吸器生理学について
- エピデミオロジー エピデミオロジー
背景:
- ヒスタミンに対する空気中の過敏反応は,慢性閉塞性肺疾患の患者で一般的です.
- 慢性呼吸器症状に対する呼吸道反応の予測価値は十分に確立されていません.
研究 の 目的:
- 呼吸道応答性の増加が慢性呼吸器系の症状の発生と寛解を予測するかどうかを調査する.
- 24年間にわたる呼吸道応答性と呼吸器系の症状の発生および解消との関連を分析する.
主な方法:
- オランダの2684人の参加者を対象とした24年間の前向きなコホート研究 (1965年−1990年).
- ヒスタミンに対するPC10 <8 mg/mLと定義される呼吸道応答性の増加.
- ロジスティック回帰分析は,年齢,性別,喫煙状況,居住地域によって調整されています.
主要な成果:
- 呼吸道応答性が高い人は,慢性的な咳,,呼吸不全,喘息発作,喘息 (OR1.7;95%CI1.2-2.3) が有意に増加した.
- 呼吸道応答性の向上は,症状の寛解の可能性が低いことと関連していました (OR 0.42; 95% CI 0.28-0.61).
結論:
- 呼吸道反応性の向上は,成人の慢性呼吸器症状の発症の有意な予測要因である.
- この過敏反応性は,既存の呼吸器系の症状の寛解と否定的に関連しており,症状の持続に役割を果たしていることを示しています.
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