マウスの骨髄におけるクローノジェニックの一般リンパ性原始体の特定

M Kondo¹, I L Weissman, K Akashi

¹Department of Pathology, Stanford University School of Medicine, California 94305, USA.

Cell

|December 11, 1997

まとめ

研究者らはマウスの骨髄で,T細胞,B細胞,NK細胞を生成できる特定の原始細胞を特定した. この発見は,早期の血液形成における一般的なリンパ性原始体の直接的な証拠を提供します.

科学分野:

血液学ヘマトロジ
免疫学免疫学とは
幹細胞生物学幹細胞生物学

背景:

共通リンパ性原始体 (CLP) の存在は,血液形成性幹細胞研究における重要かつ議論の余地のあるテーマである.
現在の造血系図には,リンパ系系統の正確な起源に関するギャップがあります.

研究の目的:

成人マウスの骨髄における特定の原始細胞集団の特性を調査する.
この集団がリンパ球受限性原始体であるかどうかを判断する.

主な方法:

成人マウスの骨髄からLin-IL-7R-Thy-1-Sca-1loc-Kitlo細胞群を分離した.
リンパ性および骨髄性分化の可能性の評価 in vivoおよびin vitro.
溶解能力を評価するための単細胞測定法.

主要な成果:

Lin (((-) IL-7R (((+) Thy-1 (((-) Sca-1loc-Kit (((lo) 集団は,リンパ球制限による急速な復元 (T,B,NK細胞) を in vivoで実証しました.
この祖先集団には,骨髄分化能力が完全に欠けていた.
この集団から1つの細胞は,T細胞とB細胞の両方を生成することができます.

結論:

この研究は,成人のマウスの骨髄に共通するリンパ性原始体の存在の直接的な証拠を提供します.
これらの発見は,血液形成系統の発達を理解する上で重要なギャップを埋めています.
特定された原始体はリンパ球に制限され,T,B,NK細胞生成に寄与する.

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