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Updated: Jul 24, 2026

RhoC GTPase Activation Assay
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Cdc42とRac1はPIによってインテグリン媒介の細胞運動性と侵入性を誘導する

P J Keely1, J K Westwick, I P Whitehead

  • 1Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7365, USA. pkeely@med.unc.edu

Nature
|December 24, 1997
PubMed
まとめ

哺乳類の上皮細胞におけるCdc42とRac1の活性化により,細胞の偏極化が乱され,侵入が促進される. このプロセスは,PI(3) Kを強調する他の経路ではなく,Phosphatidylinositol-3-OHキナーゼ (PI(3) K) シグナル伝達を必要とします.

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