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Updated: Aug 5, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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ディメリゼーション誘発による受容体タンパク質チロシンフォスファタゼ機能の阻害は,阻害ケイジを通じた

R Majeti1, A M Bilwes, J P Noel

  • 1Department of Microbiology, University of California, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|January 24, 1998
PubMed
まとめ

受容体型のタンパク質チロシンフォスファタゼ (RPTPs) の機能は,二分化によって調節されます. 変異したEGFR-CD45キメラは,あるRPTPalphaフォスファタゼドメインが別のRPTPalphaフォスファタゼドメインの触媒部位をブロックし,機能を抑制するモデルを明らかにした.

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