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Updated: Jul 25, 2026

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
15:28

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening

Published on: January 17, 2014

アイソニアジド標的 (InhA) のNADHをMycobacterium tuberculosisから改変する

D A Rozwarski1, G A Grant, D H Barton

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

Science (New York, N.Y.)
|January 24, 1998
PubMed
まとめ

望ましい結核薬であるイソニアジドは,InhA酵素に共性結合することによって作用します. この詳細なメカニズムは,イソニアジドがMycobacterium tuberculosisにおけるミコリック酸のバイオシンセシスをどのように抑制するかを明らかにしています.

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