シナプス特異的な,運動シナプスへの感覚アプリシアの長期的な促進:メモリストレージの局所タンパク質合成の機能
1Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
Cell
|January 15, 1998
まとめ
シナプス性可塑性は,細胞体から独立してニューロンの単一の分岐に起きます. この分岐特異的な変化は,新しいシナプス成長のための転写と局所的なタンパク質合成に依存しています.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- 長期にわたるシナプス可塑性は,伝統的に soma と nucleus を含む.
- シナプス性可塑性の正確な細胞の位置は,まだ調査中です.
- トランスクリプションは,長期記憶形成に不可欠であることが知られている.
研究 の 目的:
- シナプス性可塑性が特定の軸索の枝に局所できるかどうかを判断する.
- 枝特有のシナプス可塑性の基礎にある分子メカニズムを調査する.
- シナプス性可塑性における局所タンパク質合成の役割を調査する.
主な方法:
- 2つの運動ニューロンとシナプスを交わす単一の分岐したAplysia感覚ニューロンを培った.
- 長期のシナプス可塑性を誘導するために,セロトニンを1つの軸索の枝に適用します.
- シナプス結合とタンパク質合成における分岐特有の変化を分析した.
主要な成果:
- 単一の軸索の枝において,長期にわたる,枝固有の促進が実証されている.
- この可塑性はCREB媒介による転写に依存することを確認しました.
- セロトニンで治療されたブランチでのみ新しいシナプス成長が観察されました.
- プレシナプス軸索における局所的なタンパク質合成は必要であり,セロトニンによって刺激されると示した.
結論:
- シナプス可塑性は,ソマにのみ依存するものではなく,分岐特有の現象である可能性があります.
- プレシナプス軸索内の局所的なタンパク質合成は,長期的なシナプス変化をサポートするのに十分です.
- この発見は,局所化された軸索機構を含むようにシナプス可塑性の細胞単位を再定義します.
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