哺乳類の昼間の時計の光誘発によるリセットは,mPer1トランスクリプトの急速な誘導と関連しています
Y Shigeyoshi1, K Taguchi, S Yamamoto
1Department of Anatomy and Brain Science, Kobe University School of Medicine, Japan.
Cell
|January 15, 1998
まとめ
光への曝露は,哺乳類の昼間時計のmPer1を素早く誘発し,相変化と相関する. この発見は,mPer1を強調しています.
科学分野:
- クロノバイオロジー クロノバイオロジー
- 分子生物学は分子生物学である.
- 神経科学は神経科学である.
背景:
- 哺乳類の昼夜時計は,日々の生物学的リズムを調節する.
- 光は,昼間の時計を同期するための主要な環境のシグナルです.
- 光の誘導の分子メカニズムは完全に理解されていません.
研究 の 目的:
- 光誘発の昼夜時計の誘導におけるmPer1遺伝子の役割を調査する.
- mPer1誘導と昼間リズム相変化の関係を見極める.
主な方法:
- 上核 (SCN) のmPer1発現に対する光への曝露の影響を調べた.
- 光曝露とmPer1誘導の間の投与量反応関係を分析した.
- 関連したmPer1誘導と,明白なリズムにおける相変化.
主要な成果:
- mPer1 (マウス・ペリオド・ホモログ1) は,SCNで光によって素早く誘導される.
- mPer1誘導は相互性を示し,昼間の相変化と強く相関しています.
- mPer1は,光応答とフェッシングにおいて,ニューロスポラクロック遺伝子frqとの類似性を示しています.
結論:
- mPer1は,哺乳類の昼夜時計に対する光の影響を媒介する上で重要な役割を果たしています.
- mPer1の誘導は,光による昼間の時計の誘導の重要な構成要素である.
- 光感受性および無感受性オシレータは,SCN内に局在しています.
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