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Updated: Aug 19, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
09:40

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation

Published on: June 27, 2017

MAPキナーゼは,転写因子Microphthalmiaをメラノサイトにおけるc-Kitシグナル伝達と結びつける

T J Hemesath1, E R Price, C Takemoto

  • 1Division of Pediatric Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|January 24, 1998
PubMed
まとめ

Microphthalmia (Mi) とc-Kitのシグナル伝達における生殖細胞変異は,マスト細胞とメラノ細胞の発達に影響を与えます. c-Kitシグナル伝達がMAPキナーゼを活性化させ,Miをリン酸化し,色素化遺伝子の発現を向上させることを発見しました.

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