Dax1は,哺乳類の性別決定におけるSry作用を逆らいます
A Swain1, V Narvaez, P Burgoyne
1Division of Developmental Genetics, MRC National Institute for Medical Research, London, UK.
Nature
|March 5, 1998
まとめ
DAX1遺伝子は,XY個体における投与量に敏感な性転換に大きく責任があります. その発現レベルは,哺乳類の性別決定に重大な影響を及ぼし,特にSRY遺伝子アレルと相互作用するときに重要です.
科学分野:
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学について
- エンドクリノロジー エンドクリノロジー
背景:
- DAX1は,核ホルモン受容体スーパーファミリーの遺伝子であり,XP21複製を持つXY個体が女性として発達する用量感受性性逆転 (DSS) に関与しています.
- 哺乳類の性別決定には複雑な遺伝子相互作用が関与し,Y染色体上のSRYは典型的には男性の発達を開始します.
研究 の 目的:
- 投与量に敏感な性転換におけるDAX1の役割を調査する.
- 哺乳類の性決定経路における遺伝子の機能を明らかにする.
主な方法:
- 高表現レベルでDax1トランスゲンを携えたXYマウスの分析.
- Y染色体遺伝子Sry.の弱いアレルに対してDax1トランスゲンをテストする.
主要な成果:
- XYマウスにおける高レベルのDax1発現は,丸発達の遅延を引き起こした.
- XYマウスの完全な性転換は,Dax1トランスゲンが弱いSryアレルと結合されたときに発生した.
- DAX1は,投与量に敏感な性転換における主要な遺伝因子として特定されました.
結論:
- DAX1は,投与量に敏感な性転換において重要な役割を果たします.
- 精密な遺伝子発現レベルとタイミングは,哺乳類の性別決定に不可欠です.
- この研究は,早期の哺乳類の性別決定イベントを理解するためのモデルを提供します.
さらに関連する動画
05:48Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
Published on: January 2, 2018
11:49A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
Published on: August 21, 2018
関連する概念動画
01:58X-Inactivation
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
02:19The Y Chromosome Determines Maleness
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
02:45The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
02:50Dosage Compensation
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
01:58X-inactivation
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
01:15Development of the Sexual Organs in the Embryo and Fetus
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...