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心臓の先天性欠陥の手術後の30年間の感染症性内心炎の発生率
C D Morris1, M D Reller, V D Menashe
1Congenital Heart Disease Research Center, Division of Medical Informatics and Outcomes Research, Oregon Health Sciences University, Portland 97201, USA.
JAMA
|March 5, 1998
まとめ
感染症性内心炎は,子供の生まれながらの心欠陥の修復後,特に弁動脈大動脈狭窄手術後,長い間発生することがあります. 継続的な警戒と,エンドカルディティス予防に関する教育は,被災者にとって極めて重要です.
科学分野:
- ペディアトリック・カルディオロジー
- 心臓外科手術について
- 感染症 感染症は感染症です.
背景:
- kongenital heart defects (CHDs) の手術による修復後の感染症性内心炎の長期的なリスクは十分に確立されていません.
- このリスクを理解することは,患者の管理と予防戦略にとって非常に重要です.
研究 の 目的:
- 幼児期の12の特定の先天性心不全の手術による修復後の感染性内心炎 (IE) の累積的な発生率を決定する.
- 修復されたCHDの患者におけるIEの長期的なリスクの分層化を図る.
主な方法:
- 1982年に設立されたオレゴン州の人口ベースの登録が利用されました.
- 研究コホートには,オレゴン州に住む3860人が含まれ,彼らは19歳になる前に12の主要なCHDの1つで外科的な修復を受け,1993年までフォローアップしました.
- 感染症性内心炎の診断は,病院または解剖記録を通じて確認されました.
主要な成果:
- 手術後25年,累積IE発生率は欠陥によって変化した:フォロ四重症の1.3%,心室隔膜の欠陥の2.7%,大動脈の縮の3.5%,弁大動脈狭窄の13.3%,大動脈隔膜の欠陥の2.8%.
- 他の欠陥は,さまざまな追跡期間で異なった発生率を示し,第二心房隔膜欠陥の修復,パテント・ダクトス・アテリアス,または肺狭窄症の後にIE症例は報告されなかった.
- バルブ大動脈狭窄症の累積発生率が最も高く,25年後に13.3%に達した.
結論:
- kongenital heart defects (先天性心不全) を手術で修復した後に,感染性心内炎の有意かつ継続的なリスクが存在します.
- バルブ大動脈狭窄症の修復は,IEの特に高い長期的なリスクを伴う.
- 修復された心臓病の患者を対象に,心内膜炎の予防に関する患者と医療従事者の教育の強化は不可欠です.
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