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Updated: Aug 9, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

マイクロ環境におけるIRF-1の要件は,自然殺虫細胞の発達を支援するマイクロ環境におけるIRF-1の要件です

K Ogasawara1, S Hida, N Azimi

  • 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.

Nature
|March 7, 1998
PubMed
まとめ

インターフェロン調節因子-1 (IRF-1) は,自然キラー (NK) 細胞の発達に不可欠です. IRF-1は,骨髄の微小環境,特にNK細胞生成に不可欠なインタールユーキン-15を調節する.

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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
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Immune Surveillance by NK Cells and Phagocytes

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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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