インディナビールの使用に関連した内臓腹部脂肪の蓄積
K D Miller1, E Jones, J A Yanovski
1Department of Critical Care Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. kmiller@atlas.niaid.nih.gov
Lancet (London, England)
|April 3, 1998
まとめ
インディナビールを服用しているHIV患者では,腹内脂肪が増加し,腹部症状を引き起こす可能性があります. この内臓脂肪組織 (VAT) の蓄積は,インディナビルの使用とトリグリセリドの増加に関連しています.
科学分野:
- HIV/AIDSに関する研究
- 薬理学 薬理学とは
- 医学画像検査 医学画像検査
背景:
- インディナビルの併用療法を受けた一部のHIV-1患者では,腹部周長と満腹度が増加したと報告しています.
- この研究では,これらの症状が腹部脂肪分布の変化とインディナビルの使用に関連しているかどうかを調査しています.
研究 の 目的:
- インディナビルの使用がHIV-1患者における腹内脂肪の蓄積の増加と関連しているかどうかを判断する.
- 腹部症状,内臓脂肪組織 (VAT) とインディナビル治療の関係を探求する.
主な方法:
- 腹部CTスキャンでは,L4脊椎レベルでの総脂肪組織 (TAT) とVATを測定しました.
- 症状のあるインディナビル使用者,無症状のインディナビル使用者,非使用者のVAT:TAT比を比較した.
主要な成果:
- 症状のあるインディナビルの使用者は,無症状の使用者 (0.59) と非使用者 (0.40) と比較して,有意に高いVAT:TAT比率 (0.70) を有していた.
- インディナビルの治療期間と相関するVAT:TAT比率 (r=0.47,p=0.01).
- 血清トリグリセリド濃度の上昇は,より高いVAT:TAT比率と相関しています.
結論:
- インディナビル治療は,腹腔内脂肪の蓄積につながり,一部のHIV-1患者で症状を引き起こす可能性があります.
- 体脂肪の分布と基礎的なメカニズムに対するプロテアゼ阻害剤の効果に関するさらなる研究が必要である.
関連する概念動画
Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Ascites
DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...


