カルシウムチャネルブロック剤と癌のリスク
L Rosenberg1, R S Rao, J R Palmer
1Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Mass 02146, USA.
JAMA
|April 9, 1998
まとめ
カルシウムチャネルブロッカーの使用は,全体的ながんリスクを増加させません. この研究では,腎臓がんリスクとの潜在的な関連を除いて,ほとんどのがんとの関連は見つかりませんでした.
科学分野:
- 心血管薬理学について
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- 新興の証拠は,カルシウムチャネルブロッカー (CCBs) ががんリスクを高める可能性があることを示唆しています.
- 総合的および特定の癌のタイプとのCCB関連性に関する懸念があります.
研究 の 目的:
- カルシウムチャネルブロッカーの使用とがんリスクとの関連を調査する.
- CCBが全体的な癌または特定の癌のリスクを増加させるかどうかを判断する.
主な方法:
- 1983年から1996年のデータを用いて,症例対照薬物監視研究を実施した.
- 9513人のがん患者と40歳から69歳の6492人の対照群を分析した.
- この研究では,全体的ながん発生率と23種類の特定のがんの種類が調査されました.
主要な成果:
- カルシウムチャネルブロッカーの使用は,全体的ながんリスクと有意な関連性を示さなかった (RR, 1.1; 95% CI, 0.9-1.3).
- 腎臓がんを除くほとんどの個別のがんについて,有意なリスク増加は認められなかった (RR, 1.8; 95% CI, 1.1-2.7).
- 他の抗高血圧薬,ベータブロッカー,ACE阻害剤も,腎臓がんと関連していた.
結論:
- カルシウムチャネルブロッカーの使用は,全体的ながんリスクとは無関係であるようです.
- 腎臓がんを除いて,CCBは他の特定のがんのリスクの増加と有意に関連していません.
- 腎臓がんの関連性は高血圧またはその治療法に関連している可能性があります.
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