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Updated: Aug 9, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Published on: October 9, 2014

ミオトニク型ジストロフィーのCUG結合タンパク質によって調節されるスプライシングの障害

A V Philips1, L T Timchenko, T A Cooper

  • 1Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

Science (New York, N.Y.)
|May 23, 1998
PubMed
まとめ

ミオトニック・ディストロフィー (DM) は,CTGの繰り返し拡張を伴う. CUG結合タンパク質 (CUG-BP) は,拡張RNAに結合し,遺伝子のスプライシングを妨害し,疾患の病原化に寄与することで,DMを引き起こす可能性があります.

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