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Updated: Sep 22, 2026

Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death
13:54

Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death

Published on: October 21, 2012

Fasの強制的な分解は,アデノウイルスに感染した細胞におけるアポトーシスを阻害する

A E Tollefson1, T W Hermiston, D L Lichtenstein

  • 1Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, Missouri 63104-1004, USA.

Nature
|May 16, 1998
PubMed
まとめ

アデノウイルスRIDタンパク質複合体は,Fas受容体を内部化し,分解することによって細胞死を防ぐ. このメカニズムは,感染した細胞がアポトーシスを回避し,ウイルスの生存を促進するのに役立ちます.

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Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
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The Extrinsic Apoptotic Pathway

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The Intrinsic Apoptotic Pathway

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Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Intracellular Signaling Affects Focal Adhesions

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