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Updated: Jun 19, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

酸化されたLDLは,PPARgammaのリガンド活性化を通じてマクロファージの遺伝子発現を調節する

L Nagy1, P Tontonoz, J G Alvarez

  • 1The Salk Institute of Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA.

Cell
|May 6, 1998
PubMed
まとめ

マクロファージによる酸化されたLDLの吸収は,PPARgammaを活性化する新しい経路を誘発する. 特定の酸化脂質である9-HODEと13-HODEは,内在的なPPARgammaリガンドとして作用し,動脈硬化症における泡細胞遺伝子発現を潜在的に調節します.

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