毒性の高いヘリコバクター・ピロリ菌株と心不全性疾患の関連性
V Pasceri1, G Cammarota, G Patti
1Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Circulation
|May 20, 1998
まとめ
慢性ヘリコバクター・パイロリ感染症は,心不全性疾患と関連しています. 細菌だけでなく,より毒性の高いCagA陽性菌株は,リスクの増加と関連しており,アテロゲネシスの役割を示唆しています.
科学分野:
- 心臓病学 心臓病学
- 感染症 感染症は感染症です.
- 胃腸内科 胃腸内科
背景:
- 以前の研究では,ヘリコバクター・パイロリ感染症と発血性心臓病 (IHD) の間の関連が示唆されています.
- この関連における細菌の毒性の役割と混同因子 (年齢,社会階級) の役割は不明である.
研究 の 目的:
- ヘリコバクター・パイロリ感染症,特に毒性の高いCagA陽性菌株,および心不全性疾患との関連性を調査する.
- 観察された関連が細菌の毒性または混同因子によるものであるかどうかを判断する.
主な方法:
- 88人のIHD患者と88人の対照群を対象としたケース・コントロール研究.
- ヘリコバクター・パイロリ感染症とCagA陽性菌株の推定有病率.
- 年齢,性別,心血管疾患の危険因子,社会階級に調整されています.
主要な成果:
- ヘリコバクター・パイロリ菌感染症は,対照群 (40%) よりも,IHD患者 (62%) で有意に多く見られた OR=2.8.8.
- CagA陽性菌株の有病率は,対照群 (17%),OR=3.8.8.) と比較して,IHD患者 (43%) で有意に高かった.
- CagA陰性菌株の有病率は,IHD患者 (19%) と対照群 (23%),OR=0.8.8の間に差異はなかった.
結論:
- ヘリコバクター・パイロリとIHDとの関連は,より毒性の高い細菌株と関連しています.
- これらの発見は,Helicobacter pyloriが慢性炎症経由でアテロゲネシスに寄与する可能性があるという仮説を支持する.
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