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コルヒシンによる再発性心膜炎の治療. 10年以上の経験が集まっています
Y Adler1, Y Finkelstein, J Guindo
1Department of Cardiology, Rabin Medical Center, Petah Tiqva, Israel.
Circulation
|June 17, 1998
まとめ
コルヒシンは,急性心膜炎の一般的な合併症である再発性心膜炎を予防する有望な効果を示しています. この抗炎症薬は,特にイディオパシー症例では,効果的な補助または初期治療として役立つ可能性があります.
科学分野:
- 心臓病学 心臓病学
- 内科内科は,内科の内科である.
- 薬理学 薬理学とは
背景:
- 再発性 perikarditisは,急性 perikarditisを有する患者の15-32%に影響します.
- 再発の原因はしばしば不明ですが,ウイルス感染症や心臓外科手術後の心臓外科手術を含むことがあります.
- 現在の予防戦略には,NSAIDs,コルチコステロイド,免疫抑制剤,およびpericardiectomyが含まれていますが,完全に確立された最適な方法はありません.
研究 の 目的:
- 再発性 perikarditis のエピソードを予防するためのコルヒシンの有効性と安全性をレビューする.
- 最近のデータに基づいて,再発性心膜炎の補助または初期治療としてコルチキンを評価する.
主な方法:
- 過去10年間に蓄積された新しい試験データのレビュー.
- コルキシンで治療された51人の患者で実施された大規模な多センター国際研究の結果の分析.
- 患者の追跡は最大10年間.
主要な成果:
- コルヒシンは,小規模な研究で,心膜炎の再発を予防することに成功していることが示されています.
- 51人の患者を対象とした大規模な国際研究では,コルキシンによる治療が陽性であることを示した.
- この薬の有効性は,家族性地中海熱の治療に実証された使用によって支持されています.
結論:
- コルヒシンは,再発性心膜炎の従来の治療に有望な補助剤です.
- コルチキンは,特にイディオパシー性 perikarditis の初期治療の選択肢として考慮することができます.
- 証拠は,コロチシンの有効性と安全性を支持し, perikarditis の再発を予防します.
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