HTLV-I タックスタンパク質はMEKK1に結合し,イカッパBキナーゼ活性とNF-カッパB活性化を刺激する

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M J Yin1, L B Christerson, Y Yamamoto

  • 1Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8594, USA.

Cell
|June 18, 1998
PubMed
まとめ

HTLV-I Taxタンパク質は,MEKK1に結合することによってNF-kappaBシグナル伝達を活性化し,IKKbetaの活性性を高めます. この相互作用は,イカッパBαの分解を促進し,NF-カッパBの核転位と炎症反応につながります.

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