関連する実験動画
Updated: Feb 7, 2026

07:59
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
Published on: June 18, 2017
11.7K
哺乳類の脊髄における静かなグルタマタージックシナプスとノシセプション
Nature
|June 26, 1998
まとめ
セロトニン (5-ヒドロキシトリプタミン,5-HT) は,脊髄の背中角にある静かなグルタマタージックシナプスを活性化させます. この静かなシナプスの機能的なシナプスへの変容は,中枢神経系の可塑性にとって重要なメカニズムを表す可能性があります.
科学分野:
- 神経科学は神経科学である.
- 脊髄生理学 脊髄生理学
- シナプスの可塑性
背景:
- 脊髄の表面背部の角にあるニューロンは,周辺的感覚情報を伝達する.
- 背中角のいくつかの感覚シナプスは非効率または静かであり,効果的な信号伝送を妨げています.
- 小さいポストシナプス電流または高いアクションポテンシャルの値のために,非効率的な伝送が発生することがあります.
研究 の 目的:
- 表面背中角の静かなシナプスの存在と特徴を調査する.
- これらの静かなシナプスを調節するセロトニン (5-ヒドロキシトリプトミン,5-HT) の役割を決定する.
- 脊髄の中央可塑性の潜在的な細胞メカニズムを探求する.
主な方法:
- 腰椎脊髄の表面背部の角にあるニューロンからの電気生理学的記録.
- シナプス反応を評価するために,保持膜ポテンシャルを操作する.
- セロトニン (5-HT) がシナプス伝達に及ぼす影響を観察するための応用.
主要な成果:
- 応答を誘発するために去極化保持ポテンシャル (+40 mV) を要求する表面的背部の角ニューロンにおける静かなグルタマタージックシナプスを特定した.
- セロトニン (5-HT) がこれらの静かなグルタマタージックシナプスを機能的なシナプスに変換することを実証しました.
- ラフェ-脊髄経路からの神経伝達物質である5-HTが,以前に反応しなかったシナプスを活性化することを観察した.
結論:
- 静かなグルタマタージックシナプスは,脊髄の表面的背中角に存在します.
- セロトニン (5-HT) は,静かなシナプスを活発で機能的なシナプスに変換する上で重要な役割を果たします.
- 5-HTによる静かなシナプスの変換は,脊髄の中央の可塑性の基礎にある重要な細胞機構を表しています.
関連する概念動画
The Spinal Cord
31.9K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.9K
Nociception
33.3K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.3K
Spinal Cord: Information Processing
3.6K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.6K
Spinal Cord: Gross Anatomy
5.9K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.9K
Spinal Cord
1.9K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.9K
The Synapse
133.5K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
133.5K

