子供の風邪の治療のための亜鉛グルコナートパズル:ランダム化制御試験
M L Macknin1, M Piedmonte, C Calendine
1Department of Pediatrics and Adolescent Medicine, Cleveland Clinic Foundation, Ohio 44195, USA.
JAMA
|June 27, 1998
まとめ
亜鉛グルコナートグリシン (ZGG) 錠剤は,子供および青少年における風邪の持続時間を短縮しませんでした. この研究では,症状の解消時間における有意な差異は認められず,亜鉛群では副作用の増加が報告されました.
科学分野:
- 小児の健康に関する小児保健
- 感染症 感染症は感染症です.
- 栄養科学とは,栄養科学である.
背景:
- 風邪は広範囲に広がる病気で,著しい罹病率と経済的負担を引き起こしています.
- 亜鉛は生化学的に,潜在的風邪治療として提案されています.
- 亜鉛グルコナートグリシン (ZGG) 錠剤は,成人における風邪の持続時間を減らすのに有効であることが示されています.
研究 の 目的:
- 子どもと青少年における風邪の症状の治療におけるZGGパズルの有効性を評価する.
- 症状解消時間と小児集団における有害効果に対するZGGの影響を評価する.
主な方法:
- 2つの学区の249人の生徒 (1-12年生) を対象としたランダム化,二重マスク,プラセボ対照試験.
- 参加者は,少なくとも2つの風邪の症状を経験した際,ZGGパズル (10mg) またはプラセボを受けた.
- 症状の解消は,咳,頭痛,うなり声,筋肉痛,鼻の詰まり,鼻の排水,喉の掻き,喉の痛み,ひしゃみについて,毎日追跡されました.
主要な成果:
- ZGGとプラセボ群の間ですべての風邪症状の解消までの時間 (両者にとって平均9日) に大きな違いはありませんでした.
- 個々の症状の解消時間において,有意な差異は認められなかった.
- ZGGグループは,プラセボグループと比較して,味の悪さ,吐き気,口腔/喉の不快感を含む副作用の割合が高く報告されました.
結論:
- ZGGパズルは,子供や青少年における風邪の症状の治療に効果がないことが判明しました.
- インフルエンザの症状管理における亜鉛の役割を明らかにするために,ウイルス学的検査を含むさらなる研究が推奨されています.
- この研究は,小児の集団におけるZGG使用に関連する潜在的な有害効果を強調しています.
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