関連する実験動画
Updated: Jul 25, 2026

08:40
Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
SUR-8は,レウシンに富んだ繰り返しを持つ保存されたRas結合タンパク質で,C. elegansのRas媒介シグナリングを正に調節する
1Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, 80309-0347, USA.
Cell
|July 23, 1998
まとめ
新型遺伝子"sur-8"は,C. elegansの発達におけるRas信号伝達を正面に調節する. SUR-8タンパク質はRasに直接結合し,信号伝達に影響を与え,人間のRas経路の相互作用に関する洞察を提供します.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学とは
背景:
- Ras媒介の信号伝達は,細胞プロセスにとって極めて重要です.
- 発達経路における規制遺伝子の理解は不可欠です.
研究 の 目的:
- Rasシグナル伝達に関与する新しい遺伝子を特定し,特徴づけること.
- C. elegans vulval の発達における sur-8 遺伝子の役割を明らかにする.
主な方法:
- C. elegans. の遺伝子解析について
- 遺伝子機能と用量に関する研究.
- タンパク質相互作用アッセイ タンパク質相互作用アッセイ
主要な成果:
- 新型遺伝子のsur-8.8を特定し,特徴づけました.
- sur-8がRas信号伝達を正面に調節することを実証した.
- 決定されたsur-8は,Rasの下流または平行に作用し,Rafの上流に作用する.
- SUR-8タンパク質は Rasを直接結合する.
- 人間のSUR-8ホモログはK-RasとN-Rasを結合する.
結論:
- sur-8は,Ras媒介の信号伝導の重要な陽性調節器である.
- SUR-8とRasの直接的な相互作用は,その機能にとって極めて重要です.
- 保存されたSUR-8機能は,人間のRas信号伝達経路における重要性を示唆しています.
関連する概念動画
Rab Proteins
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...
Cell Polarization by Rho Proteins
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Small GTPases - Ras and Rho
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
MAPK Signaling Cascades
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...

