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Updated: Aug 16, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

V(D) Jリコンビナーゼ誘導は,体Bリンパ球において,抗原受容体シグナル伝達によって抑制される

M Hertz1, V Kouskoff, T Nakamura

  • 1National Jewish Medical and Research Center, Division of Basic Sciences, Department of Pediatrics, Denver, Colorado 80206, USA.

Nature
|July 31, 1998
PubMed
まとめ

B細胞抗原受容体 (BCR) 信号伝達は,Bリンパ球におけるDNA再結合を調節する. この過程はV(D) J再結合として知られており,免疫耐性および免疫応答に不可欠ですが,その誘導は未成熟細胞と成熟細胞の間で異なります.

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