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超音波による微小泡の血管内破壊の直接in vivo視覚化とその組織への局所的な効果

D M Skyba¹, R J Price, A Z Linka

¹Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA.

|August 26, 1998

まとめ

超音波は微小泡をin vivoで破壊し,微小血管の破裂と細胞損傷を引き起こす. このバイオエフェクトは,標的の薬物投与と腫瘍破壊の可能性を示しています.

科学分野:

バイオメディカルエンジニアリング
超音波技術について
マイクロ血管研究

背景:

超音波による血管内微小泡の破壊を調査する.
マイクロバブルカビテーションのバイオ効果を特徴づける.

研究の目的:

超音波による微小泡の破壊を観察し,特徴づけること in vivo.
超音波のエネルギーを,その結果生じる生物学的効果と相関させるため.

主な方法:

腸内顕微鏡を用いてネズミのスピノトラペシウス筋を視覚化しました.
マイクロバブルの破壊を誘発するために提供された超音波エネルギー.

主要な成果:

マイクロバブルの破壊は,マイクロ血管,主に毛細血管の破裂につながりました.
隣接する組織は,非活性の細胞の産生を示した.
超音波エネルギーとマイクロ血管破裂/細胞損傷 (P<0.001) の間には線形相関が認められた.

結論:

超音波はマイクロバブルを効果的に破壊し,局所的なバイオ効果を引き起こすことができます.
潜在的応用には,標的型薬物投与,血管新生,血管再構築,腫瘍破壊などがあります.

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