関連する実験動画

Updated: Oct 28, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

後期期LTPの維持には,PKA依存のAMPA受容体合成の増加が伴います

A Nayak1, D J Zastrow, R Lickteig

  • 1Neuroscience Program, University of Colorado Health Sciences Center, Denver 80262, USA.

Nature
|August 26, 1998
PubMed
まとめ

記憶に不可欠な後期LTPは,シナプス前遺伝子転写を必要としません. 代わりに,PKA依存の転写によって駆動されるAMPA受容体合成を含むポストシナプスメカニズムが,この重要な形態のシナプス可塑性を維持します.

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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