阻害性睡眠無呼吸症と無症状の肥満患者の交感性活動
K Narkiewicz1, P J van de Borne, R L Cooley
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.
Circulation
|September 4, 1998
まとめ
肥満だけでは,筋肉交感神経活動 (MSNA) を増加させない. しかし,肥満患者の隠された阻害性睡眠時無呼吸症 (OSA) は,MSNAを著しく上昇させ,OSAがこの集団における交感性活性化の主要な原動力であることを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- スリープ・メディシン (睡眠医学)
- メタボリック障害 メタボリック障害
背景:
- 肥満は,筋肉の交感神経活動 (MSNA) の増加と関連しています.
- 阻害性睡眠時無呼吸症 (OSA) も,MSNAの上昇と関連しています.
- 肥満におけるOSAの高い流行は,肥満におけるMSNAの理解を複雑にする.
研究 の 目的:
- 肥満そのものが,OSAから独立して,MSNAを上昇させるかどうかを判断する.
- 肥満患者のMSNA測定における潜在的な混同因子としてのOSAの役割を調査する.
主な方法:
- 正常体重および肥満の被験者におけるMSNAの測定値.
- ポリソムノグラフィーを用いて,すべての参加者をOSAのためにスクリーニングしました.
- 研究前に高血圧またはOSAと診断された個人を除外した.
主要な成果:
- OSAのない肥満患者は,正常体重の被験者と同じようなMSNAを持っていた.
- 肥満患者のサブセットには,未診断の (隠された) OSA がありました.
- 隠されたOSAを持つ肥満者は,OSAのない正常体重および肥満者と比較して,MSNAが著しく高かった.
結論:
- 肥満自体は,筋肉の交感神経活動の増加と関連していません.
- 隠された阻害性睡眠時無呼吸症候群は,肥満者におけるMSNAの上昇に大きく貢献しています.
- 肥満だけではなく,OSAは,筋肉血管への交感性流出の増加を誘導するようです.
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