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DNA複製とダメージチェックポイント経路は,Crt1抑制体の抑制によって転写を誘導する

M Huang1, Z Zhou, S J Elledge

  • 1Howard Hughes Medical Institute, Verna & Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.

Cell
|September 19, 1998
PubMed
まとめ

イーストのCRT1遺伝子はDNA損傷反応の調節体として作用し,複製ストレス中に細胞死亡を防ぐ. DNAを結合することによって遺伝子発現を制御し,DNA損傷によって抑制され,保存された負のフィードバックループを形成します.

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