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Updated: Aug 11, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

タンパク質キナーゼPDK1を通じてフォスホイノシチド3キナーゼによって制御されるタンパク質キナーゼCイソタイプ

J A Le Good1, W H Ziegler, D B Parekh

  • 1Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Science (New York, N.Y.)
|September 25, 1998
PubMed
まとめ

タンパク質キナーゼB (PKB) キナーゼPDK1はPKC同型,特にPKCzetaとPKCdeltaをリン酸化する. このリン酸化は,フォスホイノシチド3キナーゼ (PI3キナーゼ) に依存した方法で発生し,PKCシグナル伝達経路におけるPDK1の重要な調節作用を示唆する.

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