軟骨性線維症患者のオクサロバクター・フォーミゲンスの欠如:高酸素性尿症の危険因子
Lancet (London, England)
|October 6, 1998
まとめ
腸内細菌Oxalobacter formigenesが欠けていたシスティック線維症の患者は,高酸素症と腎臓石のリスクが高くなります. この欠乏は,しばしば抗生物質によるもので,腸内細菌系を永久に変化させ,オキサラートの吸収を増加させる可能性があります.
科学分野:
- 微生物学 微生物学とは
- ネフロロジーはネフロロジーを用います.
- 胃腸内科 胃腸内科
背景:
- 性線維症 (CF) の患者は,高酸素性尿症,腎カルチノーシス,およびカルシウム酸化塩酸ウロリチアシスのリスクが高くなります.
- 腸内細菌Oxalobacter formigenesは,オキシラートホメオスタシスに役割を果たしています.
- O.formigenesの喪失は,高酸素症と腎臓石の形成の増加と関連しています.
研究 の 目的:
- CF患者のO.formigenesの欠如とハイパーオキシアルウリアの間の相関を調査する.
- O.formigenesのコロニー化がCF患者と健康な個体間で異なっているかどうかを判断する.
主な方法:
- 43人のCF患者と21人の健康なボランティア (3~9歳) の糞便サンプルを,培養とDNA分析を通じてO.formigenesの分析を行った.
- オキシラート濃度やその他の石に関連する要因を測定するために,24時間の尿サンプルを採取した.
主要な成果:
- O. formigenesのコロニー化は,健康なボランティア (71%) と比較して,CF患者 (16%) で著しく低かった.
- O. formigenesを持たない36人のCF患者のうち19人 (53%) が高酸素症を発症し,若い患者ではより重症であった.
- O.formigenesでコロニー化されたCFの患者は,尿中の正常なオキシラート濃度を示した.
結論:
- CF患者におけるO.formigenesの欠如は,オキシラート吸収の増加と関連しており,高酸素症および関連する合併症のリスクを高めます.
- 長期にわたる抗生物質の使用とCFに関連する胃腸の変化は,CF患者のO.formigenesの恒久的な脱コロニゼーションを引き起こす可能性があります.
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