ジャルヴィック2000 心臓: 筋細胞回復への橋渡しの可能性
S Westaby1, T Katsumata, R Houel
1Oxford Heart Centre, Oxford, UK.
Circulation
|October 14, 1998
まとめ
Jarvik 2000 Heartは,心内軸流量ポンプであり,心不全の治療において有望であることを示しています. この血液ポンプは,羊の信頼性と取り外しやすさを実証し,回復への機械的な橋渡しとして使用することを支持しました.
科学分野:
- バイオメディカルエンジニアリング
- 心血管科学の研究について
- 医療機器技術 医療機器技術について
背景:
- 循環器の機械的なサポートは,心不全管理の重要な戦略です.
- 心内軸流動プロペラポンプは,回復への機械的なブリッジへの新しいアプローチを提供します.
- 新しい血液ポンプ技術の検証は,治療選択肢の進歩に不可欠です.
研究 の 目的:
- 機械的循環支援のための新しい心内軸流動プロペラポンプであるJarvik 2000 Heartを評価するために.
- 装置の機械的信頼性,生物適合性,および血液動力学的機能を動物モデルで確認する.
- 左心室回復へのブリッジとしてのポンプの適性を評価する.
主な方法:
- ジャルヴィック2000の心臓を30頭の羊に埋め込みました.
- ポンプの回転速度の変化 (8000〜12000rpm) で血液動力学的機能の評価.
- 解剖研究と選択的なエクスプラントによる,血液溶解と血栓塞栓症を含む生物適合性の評価.
主要な成果:
- ポンプは最大8L/分までの流量を達成し,心拍数と平均動脈圧を増加させた.
- 軽微な血液溶解と,血栓栓塞栓症または一次性血栓形成の証拠は観察されなかった.
- ウォルファリンの抗凝固機能障害と外部からの電源の断絶が課題であったが,デバイスの取り外しは簡単で安全だった.
結論:
- Jarvik 2000 Heartは,機械的な循環支援のための血液ポンプ技術における重要な進歩を表しています.
- その信頼性と除去の容易さは,肌細胞回復への橋渡し,移植,または長期的なサポートのためにそのアプリケーションをサポートします.
- この装置は,心不全患者における機械的循環支援の治療範囲を拡大する.
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