シングルアフェレンスのセグメンタルおよびアセンダントのコラーテルにおける情報フローのローカル制御
J Lomelí1, J Quevedo, P Linares
1Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México DF, México.
Nature
|October 23, 1998
まとめ
脊髄のGABAインターニューロンは,感覚情報を選択的に制御する. プレシナプス阻害は,異なるアファレント繊維の枝の独立した調節を可能にし,標的神経通信を可能にします.
科学分野:
- 神経科学は神経科学である.
- 脊髄生理学 脊髄生理学
- センサリー処理 センサリー処理
背景:
- 脊椎動物の脊髄のGABAインターニューロンは,感覚アファレントのプレシナプス阻害を媒介する.
- シングルアフェレンスの異なる脊髄内枝に対するこのプレシナプス制御の選択性は不明である.
研究 の 目的:
- 個々の筋肉のスパインドルアフェレンツにおけるプレシナプス制御の局所的性質を調査する.
- アファレントのセグメンタルとアセンダントのコラーテルが独立して調節できるかどうかを判断する.
主な方法:
- 同じ筋肉のスパインドルアファレントから2つの脊髄内側線で一次アファレント脱極化の同時測定.
- L6-L7で終了し,L3 (クラークの列) まで上昇する担保から記録します.
主要な成果:
- 中央のメカニズムは,セグメンタルおよびアセンダントのコラーテラルのシナプス効果を独立に制御する存在です.
- 焦点プレシナプス阻害は,脊髄内アフェレント枝の分断を可能にします.
結論:
- 選択的プレシナプス阻害は,感覚情報フローの動的,分割された制御を可能にします.
- このメカニズムは,共通の感覚源からインプットを受け取る脊髄後シナプス標的を切り離すことができる.
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