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Updated: May 1, 2026

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
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DCC遺伝子製品は,受容体タンパク質分解を必要とするメカニズムによってアポトーシスを誘発する

P Mehlen1, S Rabizadeh, S J Snipas

  • 1Program on Aging, The Burnham Institute, La Jolla, California 92037, USA.

Nature
|October 31, 1998
PubMed
まとめ

結腸直腸がん (DCC) で削除された遺伝子は,そのリガンドであるネトリン-1が欠けると,アポトーシスを誘導することによって腫瘍を抑制します. カスパーゼ-3によるDCC分裂は,この腫瘍抑制機能に不可欠である.

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