エクトドメインの脱落は哺乳類の発達において不可欠な役割を果たします
J J Peschon1, J L Slack, P Reddy
1Immunex Corporation, Seattle, WA 98101, USA. peschon@immunex.com
Science (New York, N.Y.)
|November 13, 1998
まとめ
腫瘍死滅因子-アルファ変換酵素 (TACE) は,単にTNFalpha. このタンパク質は,正常な発達に不可欠な成長因子アルファ (TGFalpha) の変換など,他のタンパク質の放出に不可欠です.
科学分野:
- 分子および細胞生物学
- プロテアゼの機能と規制について
- タンパク質エクトドメインの流出
背景:
- 多くの細胞表面タンパク質は,溶解性レギュレータとしてタンパク質分解によって放出されます.
- 以前,腫瘍死滅因子α変換酵素 (TACE) は,主に腫瘍死滅因子α (TNFalpha) を放出することが知られていた.
研究 の 目的:
- TNFα処理を超えてTACEのより広範な役割を調査する.
- TACEが他の細胞表面タンパク質の流出に関与するかどうかを判断する.
主な方法:
- TACEのメタルプロテインアゼ-分解因子に欠けている細胞の分析.
- TACEが欠けているマウスのフェノタイプ分析.
主要な成果:
- TACEは,TNF受容体,L-セレクチン,トランスフォーミング成長因子-アルファ (TGFalpha) を含む複数の細胞表面タンパク質を処理することが判明しました.
- TACEが欠けていたマウスは発達の異常を示し,これは重要な in vivo 機能を示している.
結論:
- TACEは,TNFalphaだけでなく,さまざまなタンパク質のエクトドメインの流出に重要な役割を果たしています.
- TACEによって処理される溶解性TGFalphaは,哺乳類の正常な発達に不可欠である.
- タンパク質エクトドメインの脱落は,幅広い生理学的意味を持つ重要な生物学的プロセスです.
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