異質な心房欠損は,持続的な心房動のための基質を作り出します
1Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. jolgin@iupui.edu
Circulation
|December 8, 1998
まとめ
犬のフェノルを用いた異質な交感性デナーベーションは,持続的な心房細動 (AF) の条件を生み出しました. この標的神経障害は,電気生理学的特性を変化させ,AFの維持を容易にした.
科学分野:
- 心血管電気生理学 心血管電気生理学
- 自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous
- 心房細動の病理生理学 病理生理学
背景:
- 自律内置による影響を受ける異質な電気生理学的性質は,心房細動 (AF) を維持するために不可欠です.
- 自律的機能障害,特に交感性内置は,AFの発達と持続に役割を果たします.
研究 の 目的:
- フェノルを用いた異質な交感性デナーベーションが持続的なAFに有利な状態を誘導できるかどうかを調査する.
- 心房屈折性およびAFサイクルの長さに対する標的型交感性デナーベーションの電気生理学的効果を探求する.
主な方法:
- 15匹の犬は,心房内皮心臓フェノール投与を受け,11匹は偽手術を受けた.
- AF誘導性,有効耐火期 (ERP),AFサイクルの長さは,処置後に評価されました.
- シンパティック ([11C]ヒドロキシエフェドリン,HED) とパラシンパティック (5-[11C]メトキシベンゾベサミコール,MOBV) トレーサーを用いたポジトロン放出トモグラフィ (PET) 画像撮影により,神経の完全性を評価した.
主要な成果:
- フェノールで治療された15匹の犬のうち14匹が持続したAFを発症し,偽薬群では1匹も発症しなかった.
- フェノールの適用は,ERPを大幅に短縮し,耐火性の分散とAFサイクル長さを増加させた.
- PETイメージングでは,フェノルの適用部位でHED吸収欠陥が明らかになり,交感性デナーベーションを示し,MOBV吸収欠陥はありませんでした.
結論:
- フェノールによる異質な交感性心房不動症は,持続的なAFを効果的に促進する.
- 交感性内置の標的型破壊は,心房電生理学を変えて,AFの維持を促進します.
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