完全心筋脱差後における動性心肺反射
1Department of Internal Medicine (Cardiology), Medical College of Virginia/Virginia Commonwealth University and Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA, USA. minisi.anthony_j.@richmond.va.gov
Circulation
|December 8, 1998
まとめ
肺ではなく心臓が,主に動性心肺反射を制御する. この反射は,血量や血圧の変化に対応して,交感神経の活動を調節する.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
背景:
- 動性心肺性反射アファレントの入力源について,相反するデータが存在します.
- 心室,心房,肺の受容体は潜在的な源である.
研究 の 目的:
- 心臓受容体が動性心肺リフレクスの入力の主な源であるかどうかを判断する.
- シンパティック・アウトフローの反射制御に対する心臓の脱差の効果を評価する.
主な方法:
- 麻酔を受けた犬でシナ・アート・デナーヴェーションの実験を行った.
- 循環器リドカインを使用して心臓のヴァーガルアフェレンツが中断されました.
- 腎交感神経活動 (RSNA) は,分離前のおよび後の血液量膨張中に測定されました.
主要な成果:
- 心臓の脱差は,血量膨張に対するRSNA応答を著しく弱めた.
- 冠内ニコチンと左心房の膨張に対する反応は廃止され,心筋アフェレンスの中断が確認されました.
- 肺の膨張反応は影響を受けず,肺アファレントが無傷であることを示した.
結論:
- 心臓は,動性心肺反射のためのアファレント入力の主な源です.
- この反射は,胸部血量および血圧の変化時に交感性流出を制御するために重要である.
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